TLS® CLA (Conjugated Linoleic Acid)

• Targets stubborn belly fat
• Helps reduce overall body fat
• Assists in promoting lean muscle mass
• Decreases the amount of fat stored in your body
• Helps reduce the percentage of body fat while preserving muscle tissue
• Effects are enhanced with exercise
• CLA contains natural ingredients that can redistribute fat to fat-burning muscle tissue
• Promotes body fat loss while preserving muscle tissue
• Enhances lean body mass
• Promotes the utilization of body fat as fuel

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

CLA, or conjugated linoleic acid, was first identified in 1978. Dr. Michael Pariza was studying beef extract at the University of Wisconsin-Madison as part of his cancer research. What he found was unexpected. Dr. Pariza’s initial research suggested two important possibilities. First, that CLA helps reduce body fat and, second, that it helps maintain lean muscle tissue. These initial findings attracted great interest, and a surge of scientific studies and research followed.

TLS CLA (Conjugated Linoleic Acid) is ideal for those who have lost weight, or are losing weight, and want the extra support to keep it off. TLS CLA (Conjugated Linoleic Acid) contains natural ingredients that can help redistribute fat to fat-burning muscle tissue to assist in promoting lean muscle mass and decreasing the amount of fat stored in your body. CLA has also been shown to enhance fat breakdown (lipolysis) within the muscle tissue and create more lean muscle.*

Chromium 120 mcg
Chromium is a trace mineral that assists with burning carbohydrates and fat. It helps provide blood sugar to cells and may support normal sensitivity to insulin, potentially helping to curb cravings for sweets and carbohydrates. Because of the role it plays in the metabolism, chromium is commonly added to natural weight loss products. Chromium is naturally found in foods like yeast, mushrooms, prunes and broccoli. It is sometimes added to drinking water. According to the Food and Drug Administration (FDA), "one small study suggests that chromium picolinate may reduce the risk of insulin resistance, and therefore possibly may reduce the risk of type 2 diabetes. FDA concludes, however, that the existence of such a relationship between chromium picolinate and either insulin resistance or type 2 diabetes is highly uncertain.

Tonalin® CLA (100% Pure Safflower Oil) 1,750 mg
Tonalin® CLA is a combination of fatty acids extracted from pure safflower oil, shown to be the richest source of this ingredient. A recent long-term study reported in the American Journal of Clinical Nutrition specifically examined Tonalin® CLA and found that study participants who took 3.4 grams of Tonalin® CLA daily for one year experienced as much as a nine percent decrease in body fat mass. Tonalin® CLA is a safe, scientifically proven, effective nutritional supplement that contains no stimulants of any kind. Tonalin® CLA works in several ways: First, it may help increase and maintain lean muscle, which naturally may slim your body. Secondly, Tonalin® CLA helps to decrease the amount of fat stored in your body. The result is, as you diet, you may drop a clothing size or two without the dreaded yo-yo effect of losing and regaining weight. Why? Because you are reducing body fat, not water, which is a more permanent and healthy way to lose weight. Thirdly, research shows Tonalin® CLA may promote overall well-being in other areas that are currently being studied worldwide. For best results, exercise moderately.

What is TLS® CLA (Conjugated Linoleic Acid)?
TLS CLA (Conjugated Linoleic Acid) is conjugated linoleic acid, a fatty acid that is recognized for its role in promoting good health.

How is TLS® CLA (Conjugated Linoleic Acid) made?
TLS CLA (Conjugated Linoleic Acid) is made from a proprietary process that converts linoleic acid from safflowers into conjugated linoleic acid. (Safflower is the best source of linoleic acid.) The proprietary processing ensures the lowest levels of non-naturally occurring isomers (impurities) in the final product. When you choose TLS CLA (Conjugated Linoleic Acid), you choose a one-of-a-kind, patented CLA uniquely consistent in purity and quality. 

I took TLS® CLA and my weigh-ins increased. What’s wrong? 
If you are taking TLS CLA as directed, exercising regularly and maintaining a healthy diet, and you are gaining weight, don’t be alarmed. TLS CLA helps reduce body fat and maintain or increase lean muscle mass. Gaining or maintaining muscle mass allows the body to burn fat more effectively; however, since muscle mass weighs more than fat mass, the scale may reflect an increase in overall weight initially, though your overall body fat is decreasing. Remember, losing body fat does not always equate to losing weight, so don’t trust the scale – check your inches.

How does TLS® CLA (Conjugated Linoleic Acid) work in the body?
TLS CLA (Conjugated Linoleic Acid) works on different parts of our bodies: adipocytes, triglycerides and carnitine palmitoyltransferase. Adipocytes are fat cells. CLA helps to decrease the number and size of adipocytes, lowering your body-fat mass. Triglycerides are fats. Most dietary fat and fat in our bodies comes in the form of triglycerides. Once these fats enter your blood, an enzyme called LPL (lipoprotein lipase) hydrolyzes lipids where they are stored in adipocytes. Studies show that CLA helps to inhibit LPL activity, so overall less fat gets stored. Its how the body causes fat cells to disintegrate. By increasing the rate at which fat cells disintegrate, CLA helps decrease the number of existing fat cells stored in your body. CPT (carnitine palmitoyltransferase) is another enzyme. It transports fatty acids to the mitochondria where they are turned into the energy you need to keep going. Additional studies show that CLA promotes CPT activity, so fat is burned faster — leaving less of it hanging around to be stored in your body.* 

Are there any other health benefits of TLS® CLA (Conjugated Linoleic Acid)?
Animal studies suggest CLA may enhance the immune system. Initial animal studies have also suggested that CLA may aid in the maintenance of normal blood glucose and insulin levels.* 

Can I take TLS® CLA (Conjugated Linoleic Acid) with my prescription drug?
No clinical studies have been performed on the interactions of TLS CLA (Conjugated Linoleic Acid) with medications. Please consult your physician before starting any dietary supplementation. 

Are there any contraindications or warnings I should be aware of when taking TLS® CLA (Conjugated Linoleic Acid)?
If you are currently taking prescription medication or have an ongoing medical condition, you should consult your healthcare provider before using this product. Women who are pregnant or breastfeeding should not use this product. Keep out of reach of children.

• Anderson, R. Effects of chromium on body composition and weight loss. Nutrition Reviews. 56(9): 266-270, 1998.
• Bhattacharya, A., et al. Conjugated linoleic acid and chromium lower body weight and visceral fat mass in high-fat-diet-fed mice. Lipids. 41(5): 437-444, 2006.
• Bhattacharya, A., et al. The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice. Journal of Nutrition. 135(5): 1124-1130, 2005.
• Blankson, H., et al. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. Journal of Nutrition. 130(12): 2943-2948, 2000.
• Brown, J., et al. Conjugated linoleic acid induces human adipocyte delipidation: autocrine/paracrine regulation of MEK/ERK signaling by adipocytokines. Journal of Biological Chemistry. 279(25): 26735-26747, 2004.
• Colakoglu, S., et al. Cumulative effects of conjugated linoleic acid and exercise on endurance development, body composition, serum leptin and insulin levels. Journal of Sports Medicine and Physical Fitness. 46(4): 570-577, 2006.
• DeLany, J., et al. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. American Journal of Physiology. 276(4 pt 2): R1172-R1179, 1999.
• Gaullier, J., et al. Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. Journal of Nutrition. 135(4): 778-784, 2005.
• Kaats, G., et al. A randomized, double-masked, placebo-controlled study of the effects of chromium picolinate supplementation on body composition: a replication and extension of a previous study. Current Therapeutic Research. 59(6): 379-387, 1998.
• Kennedy, S., et al. Influence of dietary oil content and conjugated linoleic acid (CLA) on lipid metabolism enzyme activities and gene expression in tissues of Atlantic salmon (Salmo salar L.). Lipids. 41(5): 423-436, 2006.
• Moya-Camarena, S. and Belury, M. Species differences in the metabolism and regulation of gene expression by conjugated linoleic acid. Nutrition Reviews. 57(11): 336-340, 1999.
• Ostrowska, E., et al. Dietary conjugated linoleic acids increase lean tissue and decrease fat deposition in growing pigs. Journal of Nutrition. 129(11): 2037-2042, 1999.
• Pariza, M. Perspective on the safety and effectiveness of conjugated linoleic acid. American Journal of Clinical Nutrition. 79(6): 1132S-1136S, 2004.
• Pariza, M., et al. Mechanisms of action of conjugated linoleic acid: evidence and speculation. Proceedings of the Society for Experimental Biology and Medicine. 223(1): 8-13, 2000.
• Park, Y., et al. Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids. 34(3): 235-241, 1999.
• Park, Y., et al. Effect of conjugated linoleic acid on body composition in mice. Lipids. 32(8): 853-858, 1997.
• Preuss, H. and Anderson, R. Chromium update: examining recent literature 1997-1998. Current Opinion if Clinical Nutrition and Metabolic Care. 1(6): 509-512, 1998.
• Riserus, U., et al. Metabolic effects of conjugated linoleic acid in humans: the Swedish experience. American Journal of Clinical Nutrition. 79(6): 1146S-1148S, 2004.
• Riserus, U., et al. CLA and body weight regulation in humans. Lipids. 38(2): 133-137, 2003.
• Smedman, A. and Vessby, B. Conjugated linoleic acid supplementation in humans--metabolic effects. Lipids. 36(8): 773-781, 2001.
• Steck, S., et al. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. Journal of Nutrition. 137(5): 1188-1193, 2007.
• Terpstra, A., et al. Dietary conjugated linoleic acids as free fatty acids and triacylglycerols similarly affect body composition and energy balance in mice. Journal of Nutrition. 133(10): 3181-3186, 2003.
• Terpstra, A., et al. The decrease in body fat in mice fed conjugated linoleic acid is due to increases in energy expenditure and energy loss in the excreta. Journal of Nutrition. 132(5): 940-945, 2002.
• Thom, E., et al. Conjugated linoleic acid reduces body fat in healthy exercising humans. Journal of International Medical Research. 29(5): 392-396, 2001.
• Wang, Y. and Jones, P. Dietary conjugated linoleic acid and body composition. American Journal of Clinical Nutrition. 79(suppl 6): 1153S-1158S, 2004.
• West, D., et al. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. American Journal of Physiology. 275(3 pt 2): R667-R672, 1998.
• Yamasaki, M., et al. Dietary effect of conjugated linoleic acid on lipid levels in white adipose tissue of Sprague-Dawley rats. Bioscience, Biotechnology, and Biochemistry. 63(6): 1104-1106, 1999.